David Tennant
Scrooge McDuck (Voice) (24 eps)
Danny Pudi
Huey Duck (Voice) (24 eps)
Ben Schwartz
Dewey Duck (Voice) (24 eps)
Bobby Moynihan
Louie Duck (Voice) (24 eps)
Kate Micucci
Webby Vanderquack (Voice) (24 eps)
Beck Bennett
Launchpad McQuack (Voice) (24 eps)
Toks Olagundoye
Mrs. Beakley (Voice) (24 eps)
Tony Anselmo
Donald Duck (Voice) (24 eps)
Kari Wahlgren
Roxanne Featherly (voice) (12 eps)
Keith Ferguson
Johnny / Randy / Mr. Zee (voice) (10 eps)
April Winchell
Security System (voice) (6 eps)
David Kaye
Duckworth / Rhutt Betlah (voice) (6 eps)
Jim Rash
Gyro Gearloose (voice) (6 eps)
Susanne Blakeslee
Gyropudlians (voice) (5 eps)
Lance Reddick
General Lunaris (voice) (5 eps)
Natasha Rothwell
Zan Owlson (voice) (5 eps)
Julie Bowen
Lt. Penumbra (voice) (5 eps)
Chris Diamantopoulos
Darkwing Duck / Storkules / Melon (voice) (4 eps)
Rob Paulsen
Gibbous / Moonlander #1 (voice) (4 eps)
Fred Tatasciore
Gyropudlians (voice) (4 eps)
Eric Bauza
Grandpappy Beagle / Captain Farley Foghorn (voice) (4 eps)
Lin-Manuel Miranda
Fenton Crackshell-Cabrera / Gizmoduck (voice) (4 eps)
Paget Brewster
Della Duck (voice) (3 eps)
Tom Kenny
Cousin Fethry / Moonlander #2 (voice) (3 eps)
Yuri Lowenthal
DT-87 (voice) (3 eps)
Laura Bailey
Palus (voice) (3 eps)
Sam Riegel
Moonlanders (voice) (3 eps)
Josh Brener
Mark Beaks (voice) (3 eps)
Marc Evan Jackson
Bradford Buzzard (voice) (3 eps)
Kimiko Glenn
Lena (voice) (3 eps)
Libe Barer
Violet Sabrewing (voice) (3 eps)
Margo Martindale
Ma Beagle (voice) (3 eps)
Jim Cummings
Jim Starling / Darkwing Duck / Negaduck (voice) (2 eps)
Jennifer Hale
Oceanika (voice) (2 eps)
Omid Abtahi
D'jinn (voice) (2 eps)
Allison Janney
Goldie O'Gilt (voice) (2 eps)
Nia Vardalos
Selene (voice) (2 eps)
Michael Chiklis
Zeus (voice) (2 eps)
Selenis Leyva
Officer Cabrera (voice) (2 eps)
John Gemberling
Doofus Drake (voice) (2 eps)
Paul F. Tompkins
Gladstone Gander (voice) (2 eps)
Catherine Tate
Magica De Spell (voice) (2 eps)
Bernardo de Paula
José de Carioca (voice) (1 eps)
Edgar Wright
Alistair Boorswan (voice) (1 eps)
Gabe Kunda
Narrator (voice) (1 eps)
Tad Stones
Guard (voice) (1 eps)
Cree Summer
Amunet (voice) (1 eps)
John DiMaggio
Fisher (voice) (1 eps)
Grey DeLisle
Mann (voice) (1 eps)
Russi Taylor
Young Donald (voice) (1 eps)
Jack McBrayer
Past (voice) (1 eps)
Bill Fagerbakke
Present (voice) (1 eps)
Corey Burton
Ludwig Von Drake / Corvus Von Drake (voice) (1 eps)
James Adomian
Jones (voice) (1 eps)
Nicolas Cantu
B.O.Y.D. (voice) (1 eps)
Tara Platt
Doofus' Mom (voice) (1 eps)
Noah Baird
Additional Voices (voice) (1 eps)
Dee Bradley Baker
Bubba the Caveduck / Benjamin Frankloon (voice) (1 eps)
Jameela Jamil
Gandra Dee (voice) (1 eps)
Jaime Camil
Don Karnage (voice) (1 eps)
John Hodgman
John Rockerduck (voice) (1 eps)
Arturo del Puerto
Panchito Pistoles (voice) (1 eps)