Joshua Jackson
Dr. Christopher Duntsch (8 eps)
Alec Baldwin
Dr. Robert Henderson (8 eps)
Christian Slater
Dr. Randall Kirby (8 eps)
Dominic Burgess
Jerry Summers (7 eps)
Fredric Lehne
Don Duntsch (6 eps)
Molly Griggs
Wendy Young (6 eps)
Grace Gummer
Kim Morgan (6 eps)
Laila Robins
Amy Piel (5 eps)
Grainger Hines
Earl Burke (5 eps)
AnnaSophia Robb
Michelle Shughart (5 eps)
Dashiell Eaves
Stan Novak (4 eps)
Hubert Point-Du Jour
Josh Baker (4 eps)
Maryann Plunkett
Madeline Beyer (4 eps)
Jennifer Kim
Stephanie Wu (4 eps)
Kelsey Grammer
Dr. Geoffrey Skadden (voice) (4 eps)
Kelly Kirklyn
Dorothy Burke (4 eps)
Marceline Hugot
Rose Keller (3 eps)
Cristala Carter
Shelley Brennan (3 eps)
Tracy Sallows
Susan Duntsch (3 eps)
Ajay Naidu
Dr. Sasani (3 eps)
Pilar Witherspoon
Dr. Ivers (3 eps)
Shawn Andrew
Drew Sweeney (3 eps)
Danny Burstein
Ed Yarborough (2 eps)
John Wojda
Charlie Keller (2 eps)
Medina Senghore
Kayla Gibson (2 eps)
Pamela Dunlap
Mee-Maw (2 eps)
Zabryna Guevara
Jill Deleone (2 eps)
Rachel Flynn
Lucy (2 eps)
Laura Poe
Marilyn Henderson (2 eps)
Christine Pedi
Elaine Johnson (2 eps)
Michael Levi Harris
Dr. Ilya Burkov (2 eps)
Katya Stepanov
Dr. Katya Melnikov (2 eps)
Kyle Fox Douglas
Skadden Assistant (2 eps)
Perry Strong
Joe Padua (2 eps)
Spencer House
Chris 'Betts' Beton (1 eps)
Jason Kravits
Dr. Anthony (1 eps)
Greg Wood
Dr. Roman (1 eps)
Sheila Tapia
Cecilia (1 eps)
Sandra Daley
Medical Review Board (1 eps)
Alexander Pineiro
Martinez (1 eps)
Jadé Davis
Poet (1 eps)
L'ogan J'ones
Connor (1 eps)
Stink Fisher
Coach (1 eps)
Kasey Nunez
Quarterback (1 eps)
Trace Pope
Party Goer (1 eps)
Michael Genet
Dr. Lockett (1 eps)
Catrina Ganey
Mrs. Demmings (1 eps)
Brit Whittle
Dr. Andrew Phipps (1 eps)
Faith Taylor
Anna (1 eps)
Alexandra Lemus
Student (1 eps)
Mac Brydon
Patron (1 eps)
Stephen Dexter
Banker (1 eps)
Dexter McKinney
Banker (1 eps)
Norm Lewis
Dr. Bishara (1 eps)
Sean Allan Krill
Dr. Timothy Darnton (1 eps)
Miguel Cervantes
Craig James (1 eps)
Michelle Concha
Secretary (1 eps)
Marc Deliz
Garrett Kemp (1 eps)
Michiko Sasaki
Anesthesiologist (1 eps)
Angel Dillemuth
Nurse (1 eps)
Tiffany Green
Nurse (1 eps)