Michael Keaton
Samuel Finnix (8 eps)
Peter Sarsgaard
Rick Mountcastle (8 eps)
Michael Stuhlbarg
Richard Sackler (8 eps)
Kaitlyn Dever
Betsy Mallum (8 eps)
Will Poulter
Billy Cutler (8 eps)
Rosario Dawson
Bridget Meyer (8 eps)
John Hoogenakker
Randy Ramseyer (8 eps)
Will Chase
Michael Friedman (8 eps)
Mare Winningham
Diane Mallum (7 eps)
Ian Unterman
Jonathan Sackler (7 eps)
Jake McDorman
John Brownlee (7 eps)
Phillipa Soo
Amber Collins (7 eps)
Brendan Patrick Connor
Howard Udell (7 eps)
Andrea Frankle
Beth Sackler (7 eps)
Arischa Conner
Leah Turner (6 eps)
Winsome Brown
Theresa Sackler (6 eps)
Andrés Erickson
Mortimer D.A. Sackler (6 eps)
Jaime Ray Newman
Kathe Sackler (5 eps)
Lawrence Arancio
Raymond Sackler (5 eps)
Raúl Esparza
Paul Mendelson (5 eps)
Ray McKinnon
Jerry Mallum (5 eps)
Cleopatra Coleman
Grace Pell (5 eps)
Deadra Moore
Karen Johnson (5 eps)
Alayna Hester
Elizabeth Ann McClung (5 eps)
Rick Espaillat
Dr. Alan Spanos (4 eps)
Rebecca Wisocky
Cynthia McCormick (3 eps)
Carolee Carmello
Drea Price (3 eps)
Aaron Serotsky
David Haddox (3 eps)
Caitlin Mehner
Paula Greene (2 eps)
Nicholas Logan
Walt (2 eps)
Austin Freeman
Grant Simmons (2 eps)
Erin Dangler
Marianne Skolek (2 eps)
Paden Fallis
Louis Melton (2 eps)
Meagen Fay
Sister Beth Davies (2 eps)
Kenneth Tigar
Arthur Sackler (2 eps)
Helen Goldsby
Regina Carter (2 eps)
Andrea Powell
Sharon Burnham (1 eps)
Ryan Paynter
Teen (1 eps)
Amy Parrish
Judy Cohen (1 eps)
Adam Fristoe
James Comey (1 eps)
Mark Jacoby
Dr. Hershel Jick (1 eps)
Tricia Hawn
Shelly Finnix (1 eps)
Audrey Moore
Maureen Sara (1 eps)
Spencer Garrett
Larry Berger (1 eps)
Trevor Long
Rudy Giuliani (1 eps)
Amy Rutberg
Alice Fisher (1 eps)