Tom Riley
Leonardo Da Vinci (28 eps)
Laura Haddock
Lucrezia Donati (28 eps)
Elliot Cowan
Lorenzo Medici (28 eps)
Hera Hilmar
Vanessa Moschella (28 eps)
Gregg Chillin
Zoroaster (28 eps)
Eros Vlahos
Nico (28 eps)
Blake Ritson
Girolamo Riario (28 eps)
Lara Pulver
Clarice Orsini (28 eps)
Akin Gazi
Bayezid (11 eps)
Tom Bateman
Giuliano Medici (8 eps)
Sabrina Bartlett
Sophia (6 eps)
Paul Freeman
The Architect (1 eps)
John-Paul Macleod
Labyrinth Recruit (1 eps)
Ned Dennehy
Leader of the Labyrinth (1 eps)
Jude Wright
Andrea (1 eps)