Richard Armitage
Trevor Belmont (voice) (32 eps)
James Callis
Adrian Tepes / Alucard (voice) (32 eps)
Alejandra Reynoso
Sypha Belnades (voice) (32 eps)
Adetokumboh M'Cormack
Isaac (voice) (21 eps)
Jaime Murray
Carmilla (voice) (21 eps)
Bill Nighy
Saint Germain (voice) (20 eps)
Theo James
Hector (voice) (18 eps)
Graham McTavish
Vlad Dracula Tepes (voice) (14 eps)
Jessica Brown Findlay
Lenore (voice) (14 eps)
Ivana Miličević
Striga (voice) (12 eps)
Yasmine Al Massri
Morana (voice) (12 eps)
Malcolm McDowell
Varney of London (voice) (10 eps)
Marsha Thomason
Greta (voice) (10 eps)
Jason Isaacs
The Judge (voice) (10 eps)
Rila Fukushima
Sumi (voice) (10 eps)
Navid Negahban
Sala (voice) (10 eps)
Toru Uchikado
Taka (voice) (10 eps)
Peter Stormare
Godbrand (voice) (8 eps)
Emily Swallow
Lisa Tepes (voice) (6 eps)
JP Karliak
Additional Voices (voice) (5 eps)
Imari Williams
Additional Voices (voice) (5 eps)
Toks Olagundoye
Zamfir (voice) (5 eps)
Titus Welliver
Ratko (voice) (5 eps)
Matt Frewer
The Bishop (voice) (4 eps)
Tony Amendola
The Elder (voice) (4 eps)
Courtenay Taylor
Additional Voices (voice) (4 eps)
Barbara Steele
Miranda (voice) (3 eps)
Matthew Waterson
Dragan (voice) (3 eps)
Lance Reddick
The Captain (voice) (2 eps)
Sara Cravens
Additional Voices (voice) (2 eps)
Christine Adams
The Alchemist (voice) (1 eps)