Steve Buscemi
Enoch 'Nucky' Thompson (8 eps)
Kelly Macdonald
Margaret Schroeder (8 eps)
Michael Shannon
Nelson Van Alden (8 eps)
Shea Whigham
Elias 'Eli' Thompson (8 eps)
Stephen Graham
Al Capone (8 eps)
Michael Kenneth Williams
Albert 'Chalky' White (8 eps)
Vincent Piazza
Charles 'Lucky' Luciano (8 eps)
Julianne Nicholson
Esther Randolph (8 eps)
Ben Rosenfield
Willie Thompson (8 eps)
Louis Cancelmi
Mike D'Angelo (6 eps)
Nolan Lyons
Young Enoch Thompson (5 eps)
Marc Pickering
Deputy Sheriff Enoch Thompson (4 eps)
Maya Kazan
Mabel Jeffries (4 eps)
Oakes Fegley
Young Elias Thompson (3 eps)
Natalie Paul
Beatrice Carson (2 eps)
Jeffrey Wright
Valentin Narcisse (1 eps)
Boris McGiver
Sheriff Jacob Lindsay (1 eps)
John Ellison Conlee
Commodore Louis Kaestner (1 eps)
Michael Zegen
Benny Siegel (1 eps)
Paul Calderon
Arquimedes (1 eps)
Travis Tope
Joe Harper (1 eps)
Giampiero Judica
Salvatore Maranzano (1 eps)
Michael Countryman
Frank Wilson (1 eps)
Reg Rogers
Robert Hodge (1 eps)
Emma Berg
Girlfriend (1 eps)
Jason Boyle
Danny (1 eps)
Leighton Bryan
Talia Bindleman (1 eps)
Bernard Bygott
Agent #1 (1 eps)
Nicholas E. Calhoun
Sean (1 eps)
Wilbur Edwin Henry
Agent #2 (1 eps)
Ethan Herschenfeld
Pinky Rabinowitz (1 eps)
Peter Hourihan
Agent #3 (1 eps)
Ben Jeffrey
Agent #4 (1 eps)
Susan Kirby
Secretary (1 eps)
Jordan Lage
Agent #5 (1 eps)
Adam Scarimbolo
Morris (1 eps)
Alexander Stine
Phelps (1 eps)
Madeleine Yen
Young Gillian (1 eps)
Rob Ashkenas
Maranzano Thug (1 eps)
Giovanni Celentano
Lucky Luciano's First Lieutenant (1 eps)
Brett Joseph DePetrillo
Lucky Luciano Bodyguard (1 eps)
Nancy Harris
Maranzano's Receptionist (1 eps)
Jeffrey M. Marchetti
Jackie Sweaty Palm (1 eps)
Rich Petrillo
Luciano Gunman (1 eps)
Patrick M. Walsh
Luciano Thug #1 (1 eps)
Sam Yazbeck
Maranzano Thug (1 eps)