Bill Nye
Himself - Host (13 eps)
Derek Muller
Himself - Correspondent (5 eps)
Prashanth Venkataramanujam
Cookies & Cream (voice) (3 eps)
Karlie Kloss
Herself - Correspondent (3 eps)
Rachel Bloom
Herself - Special Guest (2 eps)
Cece Pleasants
Voice of Wilhelmina (2 eps)
Sanden Totten
Ebola (2 eps)
Nazeem Hussain
Himself - Correspondent (2 eps)
Joanna Hausmann
Herself - Correspondent (2 eps)
Emily Calandrelli
Herself - Correspondent (2 eps)
Zach Braff
Himself (1 eps)
Desiigner
Himself (1 eps)
Tracy Mann
Herself - Panelist (1 eps)
Sara Benincasa
Herself - Panelist (1 eps)
Jennifer Widerstrom
Herself - Panelist (1 eps)
Martin Starr
Doug the Caveman (1 eps)
Lauren Ash
Kale (1 eps)
Jeff Dye
Eggplant (1 eps)
Andi Osho
Bread (1 eps)
Heather McDonald
Beef (1 eps)
Aubrey Anderson-Emmons
The Director (1 eps)
Robb Fraley
Himself - Panelist (1 eps)
Fred Gould
Himself - Panelist (1 eps)
Julie Kennye
Herself - Panelist (1 eps)
Katrina Karkazis
Herself - Panelist (1 eps)
Jeffrey McCune Jr.
Himself - Panelist (1 eps)
Solomon Georgio
Himself - Panelist (1 eps)
Todd Barry
Vanilla (voice) (1 eps)
Sandra Bernhard
Mint Choc Chip (voice) (1 eps)
Matt Lucas
Salted Caramel (voice) (1 eps)
Mario Cantone
Strawberry (voice) (1 eps)
Margaret Cho
Pistachio (voice) (1 eps)
Cameron Esposito
Chocolate (voice) (1 eps)
Nicole Go
DJ Seahorse (1 eps)
Ryan Calo
Himself - Panelist (1 eps)
Xeji Jardin
Herself - Panelist (1 eps)
Subbarao Kambhampati
Himself - Panelist (1 eps)
Neil deGrasse Tyson
Voice of Coffee Maker (1 eps)
Salim Shaikh
Himself (1 eps)
Margaret Mitchell
Herself (1 eps)
Prof. Mark Jacobson
Himself - Panelist (1 eps)
Richard Martin
Himself - Panelist (1 eps)
Taryn O'Neill
Herself - Panelist (1 eps)
Steve Aoki
Himself (1 eps)
Chris Beedie
Himself - Panelist (1 eps)
Cara Santa Maria
Herself - Panelist (1 eps)
Donald Schultz
Himself - Panelist (1 eps)
Alton Brown
Himself (1 eps)
Hunter Pence
Himself (1 eps)
Randy Couture
Tardigrade (1 eps)
Marcus Lindsay
Tardigrade Victim (1 eps)
Andy Rossi
Tardigrade Victim (1 eps)
Moogega Cooper
Herself - Panelist (1 eps)
Hakeem Muata Oluseyi
Himself - Panelist (1 eps)
Wil Wheaton
Himself - Panelist (1 eps)
Lanre Falusi
Herself - Panelist (1 eps)
Kristen Omeara
Herself - Panelist (1 eps)
Jennifer Reich
Herself - Panelist (1 eps)
Diedrich Bader
Smallpox (1 eps)
Jim O'Heir
Rabies (1 eps)
John O'Hurley
Influenza (1 eps)
George Wendt
Polio (1 eps)
Hilarie Cash
Herself - Panelist (1 eps)
Shawn Green
Himself - Panelist (1 eps)
Jonna Mae
Herself - Panelist (1 eps)
Gustavo Sorola
Rooster Teeth (1 eps)
Geoff Ramsey
Rooster Teeth (1 eps)
Tim Gunn
Himself (1 eps)
Camille Hammond
Herself - Panelist (1 eps)
Leslie Hinkson
Herself - Panelist (1 eps)
Paul Knoepfler
Himself - Panelist (1 eps)
Nerys Benfield
Herself - Panelist (1 eps)
Travis Rieder
Himself - Panelist (1 eps)
Rachel Snow
Herself - Panelist (1 eps)