Nick Kroll
Nick Birch / Maury the Hormone Monster / Coach Steve (voice) (10 eps)
John Mulaney
Andrew Glouberman (voice) (10 eps)
Jessi Klein
Jessi Glaser (voice) (10 eps)
Jason Mantzoukas
Jay Bilzerian (voice) (10 eps)
Andrew Rannells
Matthew MacDell (voice) (10 eps)
Maya Rudolph
Diane Birch / Constance the Hormone Monstress (voice) (10 eps)
Fred Armisen
Elliot Birch (voice) (10 eps)
Jordan Peele
Ghost of Duke Ellington (voice) (10 eps)
Ayo Edebiri
Missy Foreman-Greenwald (voice) (10 eps)