Nick Kroll
Nick Birch / Maury the Hormone Monster / Coach Steve (voice) (11 eps)
John Mulaney
Andrew Glouberman (voice) (11 eps)
Jessi Klein
Jessi Glaser (voice) (11 eps)
Jenny Slate
Missy Foreman-Greenwald (voice) (11 eps)
Jason Mantzoukas
Jay Bilzerian (voice) (11 eps)
Andrew Rannells
Matthew MacDell (voice) (11 eps)
Maya Rudolph
Diane Birch / Constance the Hormone Monstress (voice) (11 eps)
Fred Armisen
Elliot Birch (voice) (11 eps)
Jordan Peele
Ghost of Duke Ellington (voice) (11 eps)
Neil Casey
Detective Dumont / Lars (voice) (8 eps)
Richard Kind
Marty Glouberman (voice) (8 eps)
Mark Rivers
Siamese Twin #1 (voice) (6 eps)
Paula Pell
Barbara Glouberman (voice) (6 eps)
Jak Knight
DeVon (voice) (6 eps)
Joe Wengert
Caleb / Lump Humpman (voice) (6 eps)
Jon Daly
Judd Birch (voice) (6 eps)
June Diane Raphael
Devin (voice) (5 eps)
Kat Dennings
Leah Birch (voice) (5 eps)
Gina Rodriguez
Gina Alvarez (voice) (5 eps)
Heather Lawless
Jenna Bilzerian (voice) (4 eps)
Seth Morris
Greg Glaser (voice) (4 eps)
Zachary Quinto
Aiden (voice) (4 eps)
Emily Altman
Vicky (voice) (3 eps)
Gil Ozeri
(voice) (3 eps)
Michaela Watkins
Cantor Dina Reznick (voice) (3 eps)
Chelsea Peretti
Cellsea (voice) (3 eps)
Rob Huebel
Mr. Lizer (voice) (3 eps)
Paul Scheer
Kurt Bilzerian (voice) (3 eps)
Ali Wong
Ali (voice) (3 eps)
Mark Duplass
Val Bilzerian (voice) (3 eps)
Ileen Goldsmith
(voice) (2 eps)
Gary Cole
Andrew's Father (voice) (2 eps)
Nathan Fillion
Nathan Fillion (voice) (2 eps)
Julie White
Kimberly (voice) (2 eps)
Julie Klausner
Cherry Marashina (voice) (2 eps)
Andy Daly
Ghost of Harry Houdini (voice) (2 eps)
Chris Redd
(voice) (2 eps)
Thandiwe Newton
Mona (voice) (2 eps)
Natasha Lyonne
Suzette (voice) (1 eps)
Piotr Michael
Siamese Twin #2 (voice) (1 eps)
Marisa Lark Wallin
Reese's Wertherspoon / Woman (voice) (1 eps)
Crissy Guerrero
(voice) (1 eps)
David Thewlis
Shame Wizard (voice) (1 eps)
Martin Short
Gordie (voice) (1 eps)
Carlos Alazraqui
Gustavo (voice) (1 eps)
David Cross
Skip Glouberman (voice) (1 eps)
Carol Kane
Menopause Banshee / Old Woman (voice) (1 eps)
Quinta Brunson
Girl (voice) (1 eps)
Tawny Newsome
(voice) (1 eps)
Retta
Duke's Mother (voice) (1 eps)
Craig Robinson
(voice) (1 eps)
Wanda Sykes
Ghost of Harriet Tubman (voice) (1 eps)
Jaboukie Young-White
(voice) (1 eps)
Rosa Salazar
Ms. Benitez (voice) (1 eps)
Rob Riggle
Sgt. Adderall (voice) (1 eps)
Bobby Berk
Bobby Berk (voice) (1 eps)
Karamo Brown
Karamo Brown (voice) (1 eps)
Tan France
Tan France (voice) (1 eps)
Fran Gillespie
(voice) (1 eps)
Antoni Porowski
Antoni Porowski (voice) (1 eps)
Jonathan van Ness
Jonathan Van Ness (voice) (1 eps)
Kristen Wiig
Jessi's Vagina (voice) (1 eps)
Jean Smart
Depression Kitty (voice) (1 eps)
Joel Kim Booster
Charles Lu (voice) (1 eps)
Judd Hirsch
Lewis Glouberman (voice) (1 eps)