Rob Paulsen
Yakko / Pinky (voice) (275 eps)
Jess Harnell
Wakko (voice) (275 eps)
Tress MacNeille
Dot (voice) (275 eps)
Maurice LaMarche
The Brain / Squit (voice) (275 eps)
Sherri Stoner
Slappy Squirrel (voice) (275 eps)
Chick Vennera
Pesto (voice) (275 eps)
John Mariano
Bobby (voice) (275 eps)
Nathan Ruegger
Skippy Squirrel (voice) (275 eps)
Nancy Cartwright
Mindy (voice) (275 eps)
Frank Welker
Runt / Buttons (voice) (172 eps)
Bernadette Peters
Rita (voice) (172 eps)
Paul Rugg
Mr. Director (voice) (7 eps)
Mary Gross
Katie's Mom (voice) (3 eps)
Jim Cummings
Narrator (voice) (2 eps)
Julie Brown
Minerva Mink (voice) (2 eps)
Luke Ruegger
The Flame (voice) (2 eps)
Cree Summer
Elmyra Duff (voice) (2 eps)
Jeff Bennett
Charlton "Baynarts" Woodchuck (voice) (2 eps)
Gail Matthius
Candie Chipmunk (voice) (1 eps)
Dan Castellaneta
Dracula (voice) (1 eps)
Adrienne Alexander
Dr. Phrankenstein (voice) (1 eps)
Ben Stein
Pip Pumphandle (voice) (1 eps)
Kath Soucie
Fifi LaFume (voice) (1 eps)
Ron Perlman
Satan (voice) (1 eps)
Tom Ruegger
Producer (voice) (1 eps)
Peter Hastings
Writer (voice) (1 eps)
Andrea Romano
Director (voice) (1 eps)
Harry Andronis
Engineer (voice) (1 eps)
Michael McKean
Spink (voice) (1 eps)
Peter Scolari
Wilford Wolf (voice) (1 eps)
Christopher Guest
Umlatt (voice) (1 eps)
Phil Hartman
Dan Anchorman (voice) (1 eps)
Kenneth Mars
Beethoven (voice) (1 eps)
John Rhys-Davies
Tympannini (voice) (1 eps)
Richard Libertini
Wally Llama (voice) (1 eps)
Dave Thomas
King Arthur (voice) (1 eps)
Jonathan Winters
Stinkbomb D. Basset (voice) (1 eps)
Julia Kato
Miss Tanaka (voice) (1 eps)