Kath Soucie
Phil DeVille / Lil DeVille (voice) (64 eps)
Dionne Quan
Kimi Watanabe-Finster (voice) (57 eps)
Elizabeth Daily
Tommy Pickles (voice) (57 eps)
Tara Strong
Dil Pickles (voice) (56 eps)
Cree Summer
Susie Carmichael (voice) (53 eps)
Nancy Cartwright
Chuckie Finster (voice) (52 eps)
Cheryl Chase
Angelica Pickles (voice) (52 eps)
Clancy Brown
Vice Principal Pangborn (voice) (12 eps)
Ann Magnuson
Miss O'Keats (voice) (11 eps)
Candi Milo
Brianna (voice) (11 eps)
Pat Musick
Harold Frumpkin (voice) (9 eps)
Pamela Adlon
Sean Butler (voice) (7 eps)
Jack Riley
Stu Pickles (voice) (6 eps)
Angelique Perrin
Paris (voice) (5 eps)
Ron Glass
Randy Carmichael (voice) (4 eps)
Hattie Winston
Lucy Carmichael (voice) (4 eps)
Melanie Chartoff
Didi Pickles (voice) (4 eps)
Shayna Fox
Savannah Shane (voice) (3 eps)
Laraine Newman
Samantha Shane (voice) (3 eps)
Ogie Banks
Edwin (voice) (3 eps)
Kate Higgins
Leslie (voice) (2 eps)
Lizzie Murray
Nicole Boscarelli (voice) (2 eps)
Fred Stoller
Mr Beaker (voice) (2 eps)
Jennifer Aquino
Chelsea (voice) (2 eps)
Bettina Bush
Alisa (voice) (2 eps)
Philece Sampler
Francine (voice) (1 eps)
Phil Proctor
Howard DeVille (voice) (1 eps)
Drake Bell
Teen Guy #3 (voice) (1 eps)
Jim Meskimen
Skeleton / Dr. Cartunian / Dr. Cartunian Sr. (voice) (1 eps)
Romeo Miller
Li'l Q (voice) (1 eps)
Dan Bucatinsky
TV Doctor / Body Cast Man (voice) (1 eps)
Howard Morris
Doctor (voice) (1 eps)
Skylar Reider
Spencer (voice) (1 eps)
Rosslynn Taylor Jordan
Girl #2 / Computer (voice) (1 eps)
Charles Duckworth
Fridge (voice) (1 eps)
Charlie Adler
Waiter (voice) (1 eps)
Dan Castellaneta
Jonathan / Phone Caller / Sailing Instructor (voice) (1 eps)
Denise Pickering
Rachel (voice) (1 eps)
Bumper Robinson
Buster / Ty (voice) (1 eps)
Hope Levy
Waitress (voice) (1 eps)
Jason Ritter
Mr. Fisk (voice) (1 eps)
Julia Kato
Kira Watanabe-Finster (voice) (1 eps)
Alanna Ubach
Java Lava Boy (voice) (1 eps)