Rob Paulsen
Yakko Warner / Pinky / Dr. Otto Scratchansniff (voice)
Jess Harnell
Wakko Warner (voice)
Tress MacNeille
Dot Warner / Marita Hippo / Hello Nurse / Mindy's Mother (voice)
Maurice LaMarche
Brain / Squit (voice)
Nancy Cartwright
Mindy (voice)
Frank Welker
Various (voice)
Chick Vennera
Pesto (voice)
John Mariano
Bobby / Gas Station Attendant (voice)
Bernadette Peters
Rita (voice)
Sherri Stoner
Slappy Squirrel (voice)
Paxton Whitehead
King Salazar (voice)
Ben Stein
Desire Fulfillment Facilitator (voice)
Jeff Bennett
Captain of the Guard / Baloney (voice)
Paul Rugg
Mr. Director (voice)
Julie Brown
Minerva Mink (voice)
Tom Bodett
Narrator (voice)
Julie Bernstein
Singer (voice)
Steven Bernstein
Singer (voice)
Bobbi Page
Singer (voice)
Nathan Ruegger
Skippy Squirrel (voice)