Kamal Haasan
Rajaraman Venkatraman (Vasool Raja)
Prakash Raj
Dr. Vishwanathan
Prabhu
Vatti
Sneha
Janaki Vishwanathan (Paapu)
Nagesh
Sriman Venkatraman
Rohini Hattangadi
Kasturi
Crazy Mohan
Professor Margabandhu
Karunas
Amit
Jayasurya
Zakir
Malavika
Priya
Ajay Rathnam
Medicine Professor
Kavithalaya Krishnan
Surgery Professor
Nithin Sathya
Neelakandan
Chitra Lakshmanan
Dr. Kalidas
Thalaivasal Vijay
Doctor
Santhana Bharathi
Gangadharan
Kaaka Radhakrishnan
Margabandhu's father
A. K. Veerasamy
Hospital cleaner
Madhan Bob
Mani Raja
Vaiyapuri
Piles Patient
E. Ramadoss
Ward Boy
Karate Raja
Raja's sidekick
Sampath Ram
Raja's sidekick
Meera Krishnan
Mani Raja's wife
Kaajal Pasupathi
Nurse
Boys Rajan
Professor
Yatin Karyekar
Anand
Benjamin
Pickpocket
Ragasiya
Dancer in the song "Cheena Thaana"