Michael York
Sherlock Holmes (voice)
Malcolm McDowell
Professor Moriarity (voice)
John Rhys-Davies
Dr. Watson (voice)
Billy West
Tom (voice)
Grey DeLisle
Red (voice)
Phil LaMarr
Spike / Policeman (voice)
Kath Soucie
Tuffy (voice)
Jeff Bergman
Butch / Droopy (voice)
Greg Ellis
Tin / Sergeant (voice)
Jess Harnell
Pan / Brett Jeremy (voice)
Richard McGonagle
Ali / First Policeman (voice)