Charlie Adler
Buster Bunny / Usher (voice)
Tress MacNeille
Babs Bunny / Big Boo / Babs' Mother / Emily Duff / Roseanne Barr / Barbara Walters / Arsenio Hall / Additional Voices (voice)
Joe Alaskey
Plucky Duck / Tupelo Toad / Johnny Carson / Ed McMahon / Elmer Fudd / Additional Voices (voice)
Don Messick
Hamton J. Pig / Radio Announcer (voice)
Jonathan Winters
Wade Pig / Superman (voice)
Edie McClurg
Winnie Pig (voice)
Frank Welker
Uncle Stinky Pig / Byron Basset / Furrball / Little Beeper / Gogo Dodo / Vinnie / Mac Duff / Additional Voices (voice)
Cree Summer
Elmyra Duff / Mary Melody / Oprah Winfrey (voice)
Sorrell Booke
Big Daddy Boo (voice)
Rob Paulsen
Fowlmouth / Johnny Pew / Banjo the Woodpile Possum / Mr. Hitcher / Manager / Additional Voices (voice)
Maurice LaMarche
Dizzy Devil / David Letterman / Horatio / Theatre Voice (voice)
Gail Matthius
Shirley the Loon / Sissy Boo (voice)
Kath Soucie
Fifi La Fume / Little Boo / Little Sneezer / Bimbette Skunk (voice) (as Kath Souci)
Candi Milo
Sweetie Pie (voice)
Paul Julian
Road Runner (archive sound) (uncredited)