Danny DeVito
Owen / Ned 'Little Ned' Lift
Billy Crystal
Larry Donner
Kim Greist
Beth Ryan
Anne Ramsey
Mrs. Lift
Kate Mulgrew
Margaret
Branford Marsalis
Lester
Rob Reiner
Joel
Bruce Kirby
DeBenedetto
Annie Ross
Mrs. Hazeltine
Oprah Winfrey
Herself
Raye Birk
Pinsky
Olivia Brown
Ms. Gladstone
Joey DePinto
Sargeant
Philip Perlman
Mr. Perlman
Stu Silver
Ramon
J. Alan Thomas
Millington
Randall Miller
Bucky
Andre Rosey Brown
Rosey
Tony Ciccone
Mr. Lopez
Larry McCormick
Announcer
Peter Brocco
Old Man
Hettie Lynne Hurtes
Reporter