Andree Maranda
Sara
Mitch Cohen
The Toxic Avenger
Jennifer Prichard
Wanda
Cindy Manion
Julie
Robert Prichard
Slug
Gary Schneider
Bozo
Pat Ryan
Mayor Belgoody
Mark Torgl
Melvin
Dick Martinsen
Officer O'Clancy
Chris Liano
Walter Harris
David Weiss
Chief of Police
Dan Snow
Cigar Face
Doug Isbecque
Knuckles
Charles Lee Jr.
Nipples
Patrick Kilpatrick
Leroy
Larry Sulton
Frank
Michael Russo
Rico
Norma Pratt
Mrs. Haskell
Andrew Craig
Fred
Ryan Sexton
Johnny
Sarabel Levinson
Melvin's Mom
Al Pia
Tom Wrightson
Reuben Guss
Dr. Snodburger
Kenneth Kessler
Toxic Avenger's Voice (voice)
Barbara Gurskey
Barbie
Rick Collins
Bully
Randy Schein
Bozo's Friend
Richard Duggan
Ice Cream Man
Donna Winter
Mayor's Secretary
Marisa Tomei
Health Club Girl (uncredited)