Ron Fazio
The Toxic Avenger / Apocalypse Inc. Executive
John Altamura
The Toxic Avenger
Phoebe Legere
Claire
Rick Collins
Apocalypse Inc. Chairman
Rikiya Yasuoka
Big Mac
Tsutomu Sekine
Announcer
Mayako Katsuragi
Masami
Shinoburyû
Shockikuyama
Lisa Gaye
Malfaire
Jessica Dublin
Mrs. Junko
Jack Cooper
Mr. Junko
Erika Schickel
Psychiatrist
Karen King
Bad Girl
Melissa Osborne
Bad Girl
Helen Wheels
Bad Girl
Bonnie Garvin
Bad Girl
Michael Jai White
Apocalypse Inc. Executive
Joe Fleishaker
Apocalypse Inc. Executive
William Decker
Apocalypse Inc. Executive
Dan Snow
Cigarface
Andrew Wolk
Pus Man
Eric Alan
Homeless Couple
William E. Benson
Father O'Reilly
Elliot Weiss
Dog Face
Arthur M. Jolly
Blind Choir Singer
Charlotte Kaufman
Blind Baby
Lily Hayes Kaufman
Toxic Child
Lisbeth Kaufman
Toxic Child
Patricia Kaufman
Diaper Changer
Jeffrey W. Sass
Good Person of Tromaville
Harry Williams Jr.
Good Person of Tromaville
David Greenspan
Good Person of Tromaville
Kei Nakata
Sumo Wrestler
Lloyd Kaufman
Sumo Wrestler / Fish Salesman (voice)
Go Nagai
Tsukudani Expert
Paul Borghese
Lou Sipher (uncredited)
Scott Leva
The Dark Rider (uncredited)
Ziko Uchiyama
Person at Odaiba Beach