Matthew Broderick
Despereaux (voice)
Dustin Hoffman
Roscuro (voice)
Emma Watson
Princess Pea (voice)
Tracey Ullman
Miggery Sow (voice)
Kevin Kline
Chef Andre (voice)
Sigourney Weaver
The Narrator (voice)
William H. Macy
Lester (voice)
Stanley Tucci
Boldo (voice)
Ciarán Hinds
Botticelli (voice)
Robbie Coltrane
Gregory (voice)
Tony Hale
Furlough (voice)
Frances Conroy
Antoinette (voice)
Frank Langella
Mayor (voice)
Richard Jenkins
Principal (voice)
Christopher Lloyd
Hovis (voice)
Charles Shaughnessy
Pietro (voice)
Patricia Cullen
Queen (voice)
McNally Sagal
Teacher (voice)
Sam Fell
Ned / Smudge (voice)