Bob Newhart
Bernard (voice)
Eva Gabor
Miss Bianca (voice)
John Candy
Wilbur (voice)
Tristan Rogers
Jake (voice)
Adam Ryen
Cody (voice)
George C. Scott
McLeach (voice)
Wayne Robson
Frank (voice)
Douglas Seale
Krebbs (voice)
Frank Welker
Joanna (voice)
Bernard Fox
Chairman / Doctor (voice)
Peter Firth
Red (voice)
Ed Gilbert
Francois (voice)
Carla Meyer
Faloo / Mother (voice)
Russi Taylor
Nurse Mouse (voice)
Peter Greenwood
Radio Announcer / Airplane Captain (voice)
Billy Barty
Baitmouse (voice)
Mickie McGowan
International Mice (voice) (uncredited)