Joe Alaskey
Erik the Newscaster (voice)
Ken Foree
Luke St. Luke (voice)
Tom Papa
El Superbeasto (voice)
April Winchell
Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice)
Dee Wallace
Trixie (voice)
Laraine Newman
Lefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice)
Cassandra Peterson
Amber (voice)
Jess Harnell
Uncle Carl (voice)
Harland Williams
Gerard the Exterminator (voice)
Rob Paulsen
Michael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice)
Debra Wilson
Cigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice)
Tom Klein
Mr. Fly (voice)
Sheri Moon Zombie
Suzi X (voice)
Brian Posehn
Murray (voice)
Tom Kenny
Rover / Otto / Old Man / Herbie (voice)
Dee Bradley Baker
Nazi Zombie (voice)
Paul Giamatti
Dr. Satan (voice)
Geoffrey Lewis
Lenny (voice)
Rosario Dawson
Velvet Von Black (voice)
John DiMaggio
Burt the Spurt (voice)
Jeff Bennett
Nerdy Patron (voice)
Danny Trejo
Rico (voice)
Carlos Alazraqui
Bennie Redriguez (voice)
Tura Satana
Varla (voice)
Bill Moseley
Otis Driftwood (voice)
Rodger Bumpass
Screaming Patron (voice)
Sid Haig
Captain Spaulding (voice)
Charlie Adler
Krongarr / Mooney McMoon / Albino Singer (voice)
Kevin Michael Richardson
Santa Baby (voice)
Daniel Roebuck
Morris Green (voice)
Christopher Corey Smith
Walla Voodoo (voice)
Zach Hanks
Walla Voodoo (voice)
Ezra Weisz
Walla Voodoo (voice)
Karen Strassman
Walla Voodoo (voice)