Alec Baldwin
Theodore Templeton (voice)
James Marsden
Tim Templeton (voice)
Amy Sedaris
Tina Templeton (voice)
Ariana Greenblatt
Tabitha Templeton (voice)
Jeff Goldblum
Dr. Armstrong (voice)
Eva Longoria
Carol Templeton (voice)
James McGrath
Wizzie (voice)
Jimmy Kimmel
Ted Templeton (voice)
Lisa Kudrow
Janice Templeton (voice)
Raphael Alejandro
Nathan / Lead Baby Ninja (voice)
Serenity Reign Brown
Meghan (voice)
David Soren
Jimbo (voice)
Nicholas Gist
The Triplets (voice)
James Ryan
Story Bear (Connie) (voice)
David P. Smith
Movie Patron (voice)
Nova Reed
Little Bo Peep Baby (voice)
Molly K. Gray
Creepy Girl (voice)
Ashlyn Lundahl
'No' Girl (voice)
Dave Needham
Glue Baby (voice)
Tom McGrath
Dr. Tiffany Hamilton (voice)
Reyn Doi
Box Kid (voice)
Collin Erker
Time Out Kid (voice)
Walt Dohrn
Baby Bouncer (voice)
April Lawrence
Acorn Center Computer (voice)
Miles Bakshi
Young Tim Voice-Over (voice)
Kristin Lowe
Pageant Mom 1 (voice)
Marjorie Cohn
Pageant Mom 2 (voice)
Connor Albrecht
Dreidel Kid (voice)