Philip Seymour Hoffman
Caden Cotard
Samantha Morton
Hazel
Jennifer Jason Leigh
Maria
Michelle Williams
Claire Keen
Catherine Keener
Adele Lack
Emily Watson
Tammy
Tom Noonan
Sammy Barnathan
Sadie Goldstein
Olive (4 years old)
Hope Davis
Madeleine Gravis
Dianne Wiest
Ellen Bascomb / Millicent Weems
Stanley Krajewski
Actor as Caden
Kristen Bush
Actress Playing Claire
Alice Drummond
Actress Playing Frances
Amy Wright
Burning House Realtor
Deirdre O'Connell
Ellen's Mother
Elizabeth Marvel
Warehouse Realtor
Charles Techman
Like Clockwork Patient
Tom Greer
Medic
Josh Pais
Ophthalmologist
Lynn Cohen
Caden's Mother
Jerry Adler
Caden's Father
Daisy Tahan
Ariel
Frank Girardeau
Plumber
Peter Friedman
Emergency Room Doctor
Daniel London
Tom
Robert Seay
David
Stephen Adly Guirgis
Davis
Joe Lisi
Maurice
Michael Medeiros
Eric
Christopher Evan Welch
Pastor
William Ryall
Jimmy
Rosemary Murphy
Frances
John Rothman
Dentist
Paul Sparks
Derek
Tim Guinee
Needleman Actor
Robin Weigert
Adult Olive
Michael Higgins
Actor Playing Man with Nose Bleed
Barbara Haas
Warehouse Actress
Greg McFadden
Actor Playing Needleman Actor
Alvin Epstein
Man with Nose Bleed
Gerald Emerick
Man in Line
Chris McGinn
Lady at Caden's Mom's
Dan Ziskie
Leg Tremor Doctor
Portia
Therapy Patient Actress
Nicholas Wyman
Soap Actor Doctor
Amy Spanger
Soap Actress Nurse
Timothy Doyle
Michael
Cliff Carpenter
Old Man
Raymond Angelic Sr.
German Doctor
Erica Fae
German Woman
Mark Lotito
Minister
Laura Odeh
Toystore Clerk
Deanna Storey
Jazz Singer
Frank Wood
Evaluative Services Doctor
Amanda R. Phillips
Emergency Room Nurse
Kat Peters
Ellen (10 years old)