Rainn Wilson
Frank Darbo
Elliot Page
Libby
Liv Tyler
Sarah
Kevin Bacon
Jacques
Gregg Henry
Detective John Felkner
Michael Rooker
Abe
Andre Royo
Hamilton
Sean Gunn
Toby
Stephen Blackehart
Quill
Linda Cardellini
Pet Store Employee
Nathan Fillion
The Holy Avenger
Don Mac
Mr. Range
Gerardo Davila
Cop
Grant Goodman
Young Frank
Paul T. Taylor
Frank Sr.
Connor Day
Teenage Frank
James Gunn
Demonswill
Mikaela Hoover
Holly
Nick Holmes
Jim
Matt Moore
Jesus / Guy In Line
Rob Zombie
Voice Of God (voice)
Steve Agee
Comic Book Store Jerk
Laurel Whitsett
Librarian
James Lentzsch
Passenger Teen
Nate Rubin
Driving Teen
Edrick Browne
Nathaniel
Danny Cosmo
Purse-snatcher
Krystal Mayo
Wheelchair Woman
Russell Towery
Chickenhawk
Mario Jiminez Jr.
Chicken
Jonathan Winkler
Transvestite
Mollie Milligan
Sarah's Sister
Gerry May
Newscaster
Valentine Miele
Line Butter
Michelle Gunn
Line Butter's Girlfriend
Darcel White Moreno
Waitress
Greg Ingram
Long-haired Hood
Lindsey Soileau
Libby's Friend
Brandon Belknap
Christian
Zach Gilford
Jerry
Lloyd Kaufman
911 Man
Tim J. Smith
Range's Technician
Mark De Alessandro
Thug Jumped On By Boltie
Cole S. McKay
Thug Set On Fire
Dominick LaBanca
Thug #1
John W. Lawson
Thug Missing Arms
William Katt
Sgt. Fitzgibbon
Christine Bently
Stoner Girl