Michael J. Fox
Stuart Little (voice)
Chazz Palminteri
Smokey (voice)
Nathan Lane
Snowbell (voice)
Geena Davis
Mrs. Little
Hugh Laurie
Mr. Little
Jonathan Lipnicki
George Little
David Alan Grier
Red (voice)
Steve Zahn
Monty (voice)
Jim Doughan
Lucky / Officer Allen (voice)
Bruno Kirby
Mr. Stout (voice)
Jennifer Tilly
Mrs. Stout (voice)
Stan Freberg
Race Announcer (voice)
Jeffrey Jones
Uncle Crenshaw
Connie Ray
Aunt Tina
Allyce Beasley
Aunt Beatrice
Brian Doyle-Murray
Cousin Edgar
Estelle Getty
Grandma Estelle
Harold Gould
Grandpa Spencer
Patrick Thomas O'Brien
Uncle Stretch
Julia Sweeney
Mrs. Keeper
Dabney Coleman
Dr. Beechwood
Miles Marsico
Anton
Jon Polito
Officer Sherman
Joe Bays
Race Starter
Taylor Negron
Salesman
Kimmy Robertson
Race Spectator
Tannis Benedict
Hot Dog Vendor
Chuck Blechen
Skipper
Westleigh M. Styer
Skipper
Larry Goodhue
Boat Registrar
Joshua Paule
New Yorker (uncredited)