Charlie Cox
Tristan Thorn
Claire Danes
Yvaine
Sienna Miller
Victoria
Ricky Gervais
Ferdy the Fence
Jason Flemyng
Primus
Mark Strong
Septimus
Rupert Everett
Secundus
Peter O'Toole
King
Michelle Pfeiffer
Lamia
Robert De Niro
Captain Shakespeare
Sarah Alexander
Empusa
Melanie Hill
Ditchwater Sal
Joanna Scanlan
Mormo
Kate Magowan
Una / Slave Girl
David Kelly
Guard
Nathaniel Parker
Dunstan Thorn
Dexter Fletcher
Skinny Pirate
Henry Cavill
Humphrey
David Walliams
Sextus
Mark Heap
Tertius
Mark Williams
Billy
Ian McKellen
Narrator (voice)
Adam Buxton
Quintus
Bimbo Hart
Young Scientist
Alastair MacIntosh
Victorian Academic
Ben Barnes
Young Dunstan Thorn
Darby Hawker
Grumpy Customer
Frank Ellis
Mr. Monday
Struan Rodger
Bishop
Julian Rhind-Tutt
Quartus
George Innes
Soothsayer
Jake Curran
Bernard
Grant Burgin
Lackey
Olivia Grant
Girl Bernard
Eliot Sumner
Yvaine's Sister
Terry Murphy
Old Pirate
Geoff Bell
Receptionist
Mark Burns
New Bishop
Rab Affleck
Pirate
Carlos Besse Peres
Pirate
Elwin 'Chopper' David
Pirate
Adam Fogerty
Pirate
Jordan Long
Pirate
Spencer Wilding
Pirate