Michael Jai White
Al Simmons / Spawn
Martin Sheen
Jason Wynn
John Leguizamo
Clown / Violator
Theresa Randle
Wanda Blake
Nicol Williamson
Cogliostro
D.B. Sweeney
Terry Fitzgerald
Melinda Clarke
Jessica Priest
Miko Hughes
Zack
Sydni Beaudoin
Cyan
Michael Papajohn
Glen, Zack's Dad
Frank Welker
The Devil Malebolgia (voice)
Tony Haney
African Liaison
Todd McFarlane
Bum
Simon Rhee
Hong Kong Military Air Base Person (uncredited)
Robia LaMorte
XNN Reporter
John Cothran, Jr.
African Liaison
Caroline Gibson
News Anchor
Marc Robinson
Punk #1
Chris Coppola
Punk #2
Jay Caputo
Punk #3
Darryl Warren
Security Guard
Mike Akrawi
Foreign Dignitary #1
Romeo Akrawi
Foreign Dignitary #2
Jack Coleman
Doctor
Laura Interval
Angela (as Laura Stepp)
Garrison M. Singer
Anesthesiologist
John Koyama
Hong Kong Military Air Base Security (uncredited)
Al Goto
Hong Kong Military Air Base Person (uncredited)
Roger Yuan
Korean Soldier (uncredited)
Angelie Almendare
Diplomat's Wife (uncredited)