Tom Hanks
Sam Baldwin
Meg Ryan
Annie Reed
Bill Pullman
Walter
Ross Malinger
Jonah Baldwin
Rosie O'Donnell
Becky
Gaby Hoffmann
Jessica
Rita Wilson
Suzy
Victor Garber
Greg
Rob Reiner
Jay
Tom Riis Farrell
Rob
Carey Lowell
Maggie Baldwin
Barbara Garrick
Victoria
Le Clanché du Rand
Barbara Reed
Kevin O'Morrison
Cliff Reed
David Hyde Pierce
Dennis Reed
Valerie Wright
Betsy Reed
Frances Conroy
Irene Reed
Tom Tammi
Harold Reed
Calvin Trillin
Uncle Milton
Caroline Aaron
Dr. Marcia Fieldstone
Linda Wallem
Loretta
LaTanya Richardson Jackson
Harriet
Tom McGowan
Keith
Steve Mellor
Wyatt
Marguerite Schertle
Baltimore Waitress
Dana Ivey
Claire
Matt Smith
Mailman
Amanda Maher
Clarise
Victor Morris
Seattle Maitre D'
Philip Mihalski
Seattle Waiter
Donald J. Lee Jr.
Seattle Detective
Mary A. Kelly
Nervous Woman on Airplane
Diane Sokolow
Tiffany Saleswoman
Hannah Cox
Jessica's Mother
Rich Hawkins
Jessica's Father
Tamara Plank
Stewardess
Michael Badalucco
New York Taxi Dispatcher
Jeff Mazzola
New York Taxi Dispatcher
Philip Levy
Taxi Driver
Julie Janney
Cynthia
Tony Zazula
Maitre D'
John Boylan
Elevator Man
Robert Livingston
Elevator Man
Butch Stevenson
Valet
Sidney Armus
Information Booth Man
Philip Anagnos
Car Driver (uncredited)
Jason Bortz
Baltimore Mail Clerk (uncredited)
Scott Duthie
Tourist (uncredited)
William Rossman
Driver (uncredited)
Nick Taylor
Bartender (uncredited)