Clive Brook
Sherlock Holmes
Miriam Jordan
Alice Faulkner
Ernest Torrence
Professor James Moriarty
Herbert Mundin
George
Reginald Owen
Dr. Watson
Alan Mowbray
Colonel Gore-King
C. Montague Shaw
Judge
Ivan F. Simpson
Faulkner
Roy D'Arcy
Manuel Lopez (uncredited)
John George
Bird Shop Thug (uncredited)
Brandon Hurst
Secretary to Erskine (uncredited)
Howard Leeds
Little Billy