Frank Welker
Scooby-Doo / Fred Jones (voice)
Mindy Cohn
Velma Dinkley (voice)
Grey DeLisle
Daphne Blake (voice)
Matthew Lillard
Shaggy Rogers (voice)
Isabella Acres
Emma Gale (voice)
Troy Baker
The Phantom / Lance Damon (voice)
Eric Bauza
K.J. (voice)
Jeff Bennett
Mike Gale/ Mel Richmond (voice)
Wayne Brady
Brick Pimiento (voice)
Vivica A. Fox
Lotte Lavoie (voice)
Kate Higgins
Meg Gale / Cathy (voice)
Peter MacNicol
Dewey Ottman (voices)
Candi Milo
Barb Damon (voice)
John O'Hurley
The Great Pauldini (voice)
Cristina Pucelli
Colette (voice)
Kevin Michael Richardson
Security Guard #1 / Hotel Clerk (voice)
Paul Rugg
Steve Trilby (voice)
Tara Sands
Nancy (voice)
Tara Strong
News Anchor / Donna (voice)
Travis Willingham
Waldo (voice)
Ariel Winter
Chrissy Damon (voice)