Frank Welker
Scooby-Doo / Fred Jones (voice)
Mindy Cohn
Velma Dinkley (voice)
Grey DeLisle
Daphne Blake (voice)
Matthew Lillard
Shaggy Rogers (voice)
Obba Babatundé
Vampire Actor #4 (voice)
Jeff Bennett
Vincent Van Helsing / Valdronya (voice)
Julianne Buescher
Vampire Actor #3 / Reporter (voice)
Christian Campbell
Bram (voice)
Jim Cummings
Jesper Poubelle / Tulie (voice)
Rob Paulsen
Sheriff / Vampire Actor #2 / Teen Vampire (voice)
Mindy Sterling
Lita Rutland (voice)
Robert Townsend
Vampire Actor #1 (voice)
Jim Wise
Henry (voice)