Frank Welker
Scooby-Doo / Fred Jones / Msicellaneous Bikers (voice)
Mindy Cohn
Velma Dinkley (voice)
Grey DeLisle
Daphne Blake (voice)
Matthew Lillard
Shaggy Rogers / Shaky Joe (voice)
Cathy Cavadini
Faith (voice)
John DiMaggio
Friz / GPS / Msicellaneous Bikers (voice)
Michael Gough
Mr. Babbit / Blair / Grad Student #1 / Bikers (voice)
Matthew Gray Gubler
Winsor (voice)
Finola Hughes
Professor Svankmajer (voice)
Maulik Pancholy
Doctor (voice)
Kevin Michael Richardson
Tex / Cop #2 / Grad Student #3 / Bikers (voice)
Fred Willard
Mr. Hubley (voice)
Dave Wittenberg
Policeman / Cop #1 / Grad Student #2 / Bikers (voice)
Gwendoline Yeo
Ms. Deitch (voice)