Frank Welker
Fred Jones / Scooby-Doo (voice)
Casey Kasem
Shaggy Rogers (voice)
Heather North
Daphne Blake (voice)
Nicole Jaffe
Velma Dinkley (voice)
Candi Milo
Charlene Otero / Museum Guide / Old Woman #1 (voice)
Maria Canals-Barrera
Sofia Otero / Old Woman #2 (voice)
Jesse Borrego
Luis Otero / Musician #2 / Suspicious Tourist (voice)
Brandon Gonzales
Jorge Otero (voice)
Castulo Guerra
Señor Fuente / Man #1 (voice)
Benito Martinez
El Curandero / Man #2 (voice)
Darlene Mendoza
Natalia Otero / Little Girl (voice)
Rita Moreno
Doña Dolores / Woman #3 (voice)
Allyse Rivera
Carolina Otero (voice)
Casey Sandino
Sebastian Otero / Little Boy (voice)
Eddie Santiago
Alejo Otero / Musician #1 (voice)
Rip Taylor
Mr. Smiley / Ghost of Señor Otero (voice)
Michael Forest
El Chuprecabra (voice)