Tobin Bell
John Kramer / Jigsaw
Donnie Wahlberg
Eric Matthews
Shawnee Smith
Amanda Young
Erik Knudsen
Daniel Matthews
Franky G
Xavier Chavez
Glenn Plummer
Jonas Singer
Emmanuelle Vaugier
Addison Corday
Beverley Mitchell
Laura Hunter
Noam Jenkins
Michael Marks
Timothy Burd
Obi Tate
Dina Meyer
Allison Kerry
Lyriq Bent
Daniel Rigg
Tony Nappo
Gus Colyard
Kelly Jones
SWAT Member Pete
Vincent Rother
SWAT Member Joe
Linette Doherty
Mother in Cancer Ward
Kofi Payton
Boy in Cancer Ward
Gretchen Helbig
Nurse in Cancer Ward
Leigh Whannell
Adam Stanheight (voice) (uncredited)
Cary Elwes
Dr. Lawrence Gordon (archive sound) (uncredited)
Ho Chow
Security Officer