Charles Fleischer
Roger Rabbit (voice)
Kathleen Turner
Jessica Rabbit (voice)
April Winchell
Young Baby Herman / Mrs. Herman (voice)
Lou Hirsch
Adult Baby Herman (voice)
Corey Burton
Droopy Dog (voice)
Frank Welker
Bull (voice)
Damian London
Fritz
Joni Barnes
Secretary
Jimmy Bracken
Cameraman
Angel Cook
Fireman