Johnny Depp
Rango / Lars (voice)
Isla Fisher
Beans (voice)
Ned Beatty
Mayor (voice)
Bill Nighy
Rattlesnake Jake (voice)
Abigail Breslin
Priscilla (voice)
Alfred Molina
Roadkill (voice)
Stephen Root
Doc / Merrimack / Mr. Snuggles (voice)
Harry Dean Stanton
Balthazar (voice)
Timothy Olyphant
Spirit of the West (voice)
Ray Winstone
Bad Bill (voice)
Ian Abercrombie
Ambrose (voice)
Gil Birmingham
Wounded Bird (voice)
James Ward Byrkit
Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice)
Claudia Black
Angelique (voice)
Blake Clark
Buford (voice)
John Cothran, Jr.
Elgin (voice)
Patrika Darbo
Delilah / Maybelle (voice)
George DelHoyo
Señor Flan - Mariachi Accordion (voice)
Maile Flanagan
Lucky (voice)
Charles Fleischer
Elbows (voice)
Beth Grant
Bonnie (voice)
Ryan Hurst
Jedidiah (voice)
Vincent Kartheiser
Ezekiel / Lasso Rodent (voice)
Hemky Madera
Chorizo (voice)
Alex Manugian
Spoons (voice)
Mark 'Crash' McCreery
Parsons (voice)
Joe Nuñez
Rock-Eye (voice)
Christopher Lee Parson
Hazel / Kinski / Stump / Clinker / Lenny / Boseefus (voice)
Lew Temple
Furgus / Hitch (voice)
Alanna Ubach
Boo / Cletus / Fresca / Miss Daisy (voice)
Gore Verbinski
Sgt Turley / Crevice / Slim / Lupe - Mariachi Violin (voice)
Kym Whitley
Melonee (voice)
Keith Campbell
Sod Buster (voice)