Lance Crouther
Pootie Tang
Jennifer Coolidge
Ireenie
J.B. Smoove
Trucky
Reg E. Cathey
Dirty Dee
Robert Vaughn
Dick Lecter
Wanda Sykes
Biggie Shorty
Chris Rock
JB / Radio DJ / Pootie's Father
Mario Joyner
Lacey
Cathy Trien
Stacy
Laura Kightlinger
Anchor Woman
Dave Attell
Frank
Rick Shapiro
Shakey
Christopher Wynkoop
Sheriff
J.D. Williams
Froggy
Missy Elliott
Diva
David Cross
Dennis
Qiana Drew
Singing Lady
Lorria Richards
Singing Lady
Andy Richter
Record Executive
Kristen Bell
Record Executive's Daughter
Cole Hawkins
Little Pootie
Tara Jeffers
Solo Girl Singer
Conan O'Brien
Conan O’Brien (uncredited)
Ebony Jo-Ann
Pootie's Mother
Bob Costas
Bob Costas
Brian Donahue
Pootie Impostor (uncredited)
Keesha Sharp
Party Girl