Rose McGowan
Cherry Darling
Freddy Rodríguez
Wray
Marley Shelton
Dr. Dakota Block
Josh Brolin
Dr. William Block
Jeff Fahey
J.T. Hague
Michael Biehn
Sheriff Hague
Bruce Willis
Lieutenant Muldoon
Rebel Rodriguez
Tony Block
Naveen Andrews
Abby
Julio Oscar Mechoso
Romey
Fergie
Tammy Visan
Nicky Katt
Joe
Michael Parks
Earl McGraw
Tom Savini
Deputy Tolo
Carlos Gallardo
Deputy Carlos
Skip Reissig
Skip
Tommy Nix
Paramedic Nixer
Quentin Tarantino
Rapist #1
Gregory Kelly
Rapist #2
Electra Avellan
Babysitter Twin #1
Elise Avellan
Babysitter Twin #2
Felix Sabates
Dr. Felix
Troy Robinson
Soldier #1
Derek Southers
Soldier #2
Jason Douglas
Lewis
Cecilia Conti
Paramedic Cecil
Danny Trejo
Machete
Jerili Romeo
Ramona McGraw
Cheech Marin
Priest
Corey Burton
Additional Narrator (voice)
Emmy Robbin
Hot Female Deputy (uncredited)
Zoë Bell
Sicko Eating Paramedic #2 (uncredited)
Robert Rodriguez
One of Abby's Henchmen (uncredited)