Paul Reubens
Pee-wee Herman
Elizabeth Daily
Dottie
Mark Holton
Francis
Diane Salinger
Simone
Judd Omen
Mickey
Irving Hellman
Mr. Crowtrey
Monte Landis
Mario
Damon Martin
Chip
David Glasser
BMX Kid
Gregory Brown
BMX Kid
Daryl Keith Roach
Chuck
Peter Looney
Policeman #2
Starletta DuPois
Sgt. Hunter
Professor Toru Tanaka
Butler
Ed Herlihy
Mr. Buxton
Ralph Seymour
Francis' Accomplice
Lou Cutell
Amazing Larry
Raymond Martino
Gang Member
Erica Yohn
Madam Ruby
Bill W. Richmond
Highway Patrolman
Alice Nunn
Large Marge
Ed Griffith
Trucker
Simmy Bow
Man in Diner
Jon Harris
Andy
Carmen Filpi
Hobo Jack
Jan Hooks
Tina
John Moody
Bus Clerk
John O'Neill
Cowboy #1
Alex Sharp
Cowboy #2
Chester Grimes
Biker #1
Luis Contreras
Biker #2
Lonnie Parkinson
Biker #3
Howard Hirdler
Biker #4
Cassandra Peterson
Biker Mama
Jason Hervey
Kevin Morton
Bob McClurg
Studio Guard
John Paragon
Movie Lot Actor
Susan Barnes
Movie Lot Actress
Zachary Hoffman
Director
Lynne Marie Stewart
Mother Superior
George Sasaki
Japanese Director
Richard Brose
Tarzan
Drew Seward
Kid #1
Brett Fellman
Kid #2
Bob Drew
Fireman
John Gilgreen
Policeman at Pet Shop
Noreen Hennessy
Reporter
Phil Hartman
Reporter
Michael Varhol
Photographer
David Rothenberg
Hobo
Patrick Cranshaw
Hobo
Sunshine Parker
Hobo
Gilles Savard
Pierre
James Brolin
Self - as "P. W."
Morgan Fairchild
Self - as "Dottie"
Tony Bill
Terry Hawthorne
Dee Snider
Self (as Twisted Sister)
Milton Berle
Self (uncredited)
Terry Bolo
Biker Chick (uncredited)
Tim Burton
Thug in Alley (uncredited)
Manuel Benitez
BMX Kid #0
Darla
Pink Poodle