Gena Rowlands
Ivy
Tony Shalhoub
Misha Vilyenkov
Cheech Marin
Ignacio
Bruce Davison
Dr. Reingold
Trini Alvarado
Adult Marie Alweather
Jay Mohr
Benny / Paulie (voice)
Buddy Hackett
Artie
Hallie Eisenberg
Marie Alweather
Matt Craven
Warren Alweather
Bill Cobbs
Virgil the Janitor
Tia Texada
Ruby / Lupe (voice)
Laura Harrington
Lila Alweather
Peter Basch
Graduate Student #1
Emily Mura-Smith
Graduate Student #2
Hal Robinson
Grandpa
Tamara Zook
Speech Therapist
Nicole Chamberlain
Shirley
Charles Parks
Gerald
Seth Mumy
Jeremy
Dig Wayne
Research Assistant #1
Michael Leydon Campbell
Research Assistant #2
Kristie Transeau
Veterinarian
Jerry Winsett
Mr. Tauper
Bud Cox
Ivy's Doctor