Michelle Pfeiffer
Melanie Parker
George Clooney
Jack Taylor
Mae Whitman
Maggie Taylor, Jack's daughter
Alex D. Linz
Sammy Parker, Melanie's son
Charles Durning
Lew, Jack's boss
Jon Robin Baitz
Mr. Yates, Jr.
Ellen Greene
Mrs. Elaine Lieberman
Amanda Peet
Celia
Joe Grifasi
Manny Feldstein
Pete Hamill
Frank Burroughs
Anna Maria Horsford
Evelyn
Gregory Jbara
Freddy
Sheila Kelley
Kristen, Jack's ex-wife
Bitty Schram
Marla
Barry Kivel
Mr. Yates, Sr.
Robert Klein
Dr. Martin
George Martin
Mr. Smith Leland
Michael Massee
Eddie Parker
Holland Taylor
Rita
Rachel York
Liza
Steven Jang
Vincent Wang
Samantha Cintrón
Rosa Lopez
Victor Truro
Sammy's Pediatrician
Ashley Greenfield
Jessica
Sidney Armus
Mayor Sidney Aikens
Hal Panchansky
Metro Reporter
Maggie Wagner
Daily News Reporter
Isabelle Ashland
Daily News Reporter
Jasmin Hartmann
Daily News Reporter
Larry Sherman
Daily News Visitor
Shaun Duke
Foreign Artist Guy
Thomas Schall
Gentleman
Michael Badalucco
Lt. Bonomo
Jeanie Van Dam
Old Woman
Kirstin Allen
Pregnant Saleslady
Michael Genet
Mayor Aikens' Press Secretary
Julia Ryder Perce
Lew's Secretary
P.J. Aliseo
Spiderman
Liam Ahern
The Incredible Hulk
José Rabelo
Museum Guard
Darla Hill
Oribe's Receptionist
Joe Avellar
Reporter
Jullie Chung
Reporter
Dale Kasman
Lady in the Police Station
Andrew Magarian
Bum in the Police Station
Katherine Argo
Passerby #1
Rob Buntzen
Passerby #2
Brian Cahill
Passerby #3
Fred Goehner
Davis
Kuniko Narai
Flower Shop Employee
Gideon Jacobs
Billy (uncredited)