Ryan Reynolds
Wade Wilson / Deadpool / Juggernaut (voice)
Josh Brolin
Cable
Morena Baccarin
Vanessa
Julian Dennison
Firefist
Zazie Beetz
Domino
T.J. Miller
Weasel
Leslie Uggams
Blind Al
Karan Soni
Dopinder
Brianna Hildebrand
Negasonic Teenage Warhead
Jack Kesy
Black Tom
Eddie Marsan
Headmaster
Shioli Kutsuna
Yukio
Stefan Kapičić
Colossus (voice)
Randal Reeder
Buck
Nikolai Witschl
Head Orderly Frye
Thayr Harris
Sergei Valishnikov
Rob Delaney
Peter
Lewis Tan
Shatterstar
Bill Skarsgård
Zeitgeist
Terry Crews
Bedlam
Brad Pitt
Vanisher
Paul Wu
Hong Kong Boss
Robert Maillet
Sluggo
Alan Tudyk
Luke - Redneck #1
Matt Damon
Redneck #2
Michasha Armstrong
Swat Captain (School)
Joe Doserro
Bus Driver
Hayley Sales
Cable's Wife
Islie Hirvonen
Cable's Daughter
Jagua Arneja
Tree Trimmer #1
Gerry South
Tree Trimmer #2
Mike Dopud
Prison Guard
Luke Roessler
Cereal Kid
Andy Canete
Neighbor #1
Tanis Dolman
Neighbor #2
Eleanor Walker
Neighbor #3
Hunter Dillon
Branding Boy
Sala Baker
Older Firefist
Sonia Sunger
News Reporter (Irene)
Paul Wernick
News Cameraman
Rhett Reese
News Helicopter Pilot
Abiola Uthman
Chinook Pilot
Tony Bailey
Black Tom Gang Member
Alex Kliner
Park Bench Couple
Elaine Kliner
Park Bench Couple
David Leitch
Ground Chuck Mutant
Valencia Budijanto
Zoo Kid
Stefania Indelicato
Bystander
Alicia Morton
Vocalist on 'Tomorrow' (voice)
Andre Tricoteux
On-Set Colossus (uncredited)
Fred Savage
Fred Savage (uncredited)
James McAvoy
Charles Xavier / Professor X (uncredited)
Nicholas Hoult
Hank McCoy / Beast (uncredited)
Evan Peters
Peter Maximoff / Quicksilver (uncredited)
Tye Sheridan
Scott Summers / Cyclops (uncredited)
Alexandra Shipp
Ororo Monroe / Storm (uncredited)
Kodi Smit-McPhee
Kurt Wagner / Nightcrawler (uncredited)
Hugh Jackman
Logan / Wolverine (archive footage) (uncredited)