John Barrymore
Riviere
Helen Hayes
Madame Fabian
Clark Gable
Jules
Lionel Barrymore
Robineau
Robert Montgomery
Auguste Pellerin
Myrna Loy
Wife of Brazilian Pilot
William Gargan
Brazilian Pilot
C. Henry Gordon
Daudet
Leslie Fenton
Jules' Radio Operator / Co-Pilot
Harry Beresford
Pierre Roblet
Frank Conroy
Radio Operator
Dorothy Burgess
Pellerin's Girlfriend
Irving Pichel
Dr. Decosta
Helen Jerome Eddy
Worried Mother
Buster Phelps
Sick Child
Ralf Harolde
Pilot
Marcia Ralston
Nightclub Vamp
Maurice Black
Nightclub Manager (uncredited)
Ed Brady
Radio Operator on Telephone (uncredited)
Sidney D'Albrook
Airport Office Employee (uncredited)
Claire Du Brey
Santiago Nurse (uncredited)
Sherry Hall
Airport Office Employee (uncredited)
Otto Hoffman
Airport Office Clerk (uncredited)
George Irving
Santiago Doctor (uncredited)
Wallace MacDonald
Mechanic (uncredited)
Michael Mark
Airport Office Employee (uncredited)
Francis McDonald
Radioman (uncredited)
Louis Natheaux
Radioman (uncredited)
Inez Palange
Simone's Maid (uncredited)
Edward Peil Sr.
Airport Office Employee (uncredited)
Evelyn Selbie
Mother in Window (uncredited)