Chevy Chase
Clark Griswold
Beverly D'Angelo
Ellen Griswold
Juliette Lewis
Audrey Griswold
Johnny Galecki
Russell 'Rusty' Griswold
John Randolph
Clark, Sr.
Diane Ladd
Nora
E.G. Marshall
Art
Doris Roberts
Francis
Randy Quaid
Cousin Eddie
Miriam Flynn
Cousin Catherine
Cody Burger
Rocky
Ellen Hamilton Latzen
Ruby Sue
William Hickey
Uncle Lewis
Mae Questel
Aunt Bethany
Sam McMurray
Bill
Nicholas Guest
Todd Chester
Julia Louis-Dreyfus
Margo Chester
Nicolette Scorsese
Mary
Keith MacKechnie
Delivery Boy
Brian Doyle-Murray
Frank Shirley
Natalija Nogulich
Helen Shirley
Tony Epper
Bozo #1
Billy Hank Hooker
Bozo #2
Alexander Folk
SWAT Officer
Jeremy Roberts
Cop
Woody Weaver
Cop
Michael Kaufman
Young Executive
Doug Llewelyn
Parade Announcer (voice)
Devin Bailey
Clark (age 9) (uncredited)
Frank Foti Jr.
SWAT Team Sargeant (uncredited)
Traci Kochendorfer
Downtown Shopper (uncredited)