Emma Thompson
Nanny McPhee
Colin Firth
Mr. Brown
Kelly Macdonald
Evangeline
Thomas Brodie-Sangster
Simon
Eliza Bennett
Tora
Jennifer Rae Daykin
Lily
Raphaël Coleman
Eric
Samuel Honywood
Sebastian
Holly Gibbs
Christianna
Hebe Barnes
Baby Agatha
Zinnia Barnes
Baby Agatha
Angela Lansbury
Aunt Adelaide
Celia Imrie
Mrs. Quickly
Imelda Staunton
Mrs. Blatherwick
Elizabeth Berrington
Letita
Derek Jacobi
Mr. Wheen
Patrick Barlow
Mr. Jowls
Adam Godley
Vicar
Claire Downes
Nanny Whetstone
Phyllida Law
Mrs. Partridge (voice)
Freya Fumic
The Voice of Baby Agatha (voice)