Bill Pullman
George Bailey
Penelope Ann Miller
Mary Hatch Bailey
Nathan Lane
Clarence
Martin Landau
Pa Bailey / Mr. Potter
Sally Field
Mrs. Bailey / Narrator
Joe Mantegna
Joseph / Nick
Christian Slater
Harry Bailey / Sam Wainwright
Jerry Van Dyke
Uncle Billy
Robert Guillaume
Mr. Gower
Carol Kane
Cousin Tilly / Mrs. Hatch
Bronson Pinchot
Mr. Carter
Dan Lauria
Bert
Craig Sheffer
Ernie Bishop / Ed / Bridgekeeper
Armelia McQueen
Mrs. Thompson
Ryan Slater
Young George Bailey / Peter Bailey
Tina Majorino
Janie Bailey
Myles Jeffrey
Tommy Bailey
Mae Whitman
Zuzu Bailey
Casey Kasem
Radio Announcer