Will Ferrell
Megamind (voice)
Tina Fey
Roxanne Ritchi (voice)
Jonah Hill
Hal Stewart / Tighten (voice)
Brad Pitt
Metro Man (voice)
David Cross
Minion (voice)
Justin Theroux
Megaminds's Father (voice)
Ben Stiller
Bernard (voice)
Jessica Schulte
Megamind's Mother (voice)
Tom McGrath
Lord Scott / Prison Guard (voice)
J.K. Simmons
Warden (voice)
Emily Nordwind
Lady Scott (voice)
Quinn Dempsey Stiller
Schoolchild (voice)
Ella Olivia Stiller
Schoolchild (voice)
Brian Hopkins
Prisoner (voice)
Christopher Knights
Prison Guard (voice)
Mike Mitchell
Father in Crowd (voice)
Jack Blessing
Newscaster (voice)
Jasper Johannes Andrews
Crying Baby (voice)
Stephen Kearin
Mayor (voice)