María Callas
Medea
Massimo Girotti
Creonte
Laurent Terzieff
Chirone
Giuseppe Gentile
Giasone
Margareth Clémenti
Glauce
Paul Jabara
Pelias
Gerard Weiss
Second Centaur
Sergio Tramonti
Apsirto, Medea's Brother
Luigi Barbini
Argonaut
Luigi Masironi
Jason at 5
Michelangelo Masironi
Jason at 13
Gianni Brandizi
Argonaut
Franco Jacobbi
Argonaut
Annamaria Chio
Wet Nurse
Piera Degli Esposti
Woman
Graziella Chiarcossi
Glauce's Maid
Rossana Canghiari
Servant of Glauce (uncredited)
Maria Cumani Quasimodo
(uncredited)
Vladimer Julukhadze
(uncredited)
Maria Smith
Maid (uncredited)
Giorgio Trombetti
(uncredited)
Rita Savagnone
Voice Dubbing: Maria Callas / Medea (voice) (uncredited)
Pino Colizzi
Voice Dubbing: Giuseppe Gentile / Jason (voice) (uncredited)
Enrico Maria Salerno
Voice Dubbing: Laurent Terzieff / Centaur (voice) (uncredited)