Danny Trejo
Machete
Jessica Alba
Sartana Rivera
Robert De Niro
Senator John McLaughlin
Steven Seagal
Rogelio Torrez
Cheech Marin
Padre Cortez
Lindsay Lohan
April Booth
Electra Avellan
Nurse Mona
Elise Avellan
Nurse Lisa
Tom Savini
Osiris Amanpour
Don Johnson
Von Jackson
Billy Blair
Von's Henchman
Jeff Fahey
Michael Booth
Shea Whigham
Sniper
Daryl Sabara
Julio
Tito Larriva
Culebra Cruzado
Gilbert Trejo
Jorge
Felix Sabates
Doc Felix
Alicia Rachel Marek
June
Marci Madison
Nurse Fine
Tina Rodriguez
Tristana
Stacy Keach
Doc Franklin
James Parks
Edgar McGraw
Ara Celi
Reporter
Mayra Leal
Chica (Naked Girl)
Tommy Nix
Dishwasher
Alejandro Antonio
Chief
Juan Gabriel Pareja
Rico
Roland Ruiz
Luis
Nina Leon
Machete's Wife
Jason Douglas
Patrolman #1
Mitchell Lance Adams
Patrolman 2
Vic Trevino
Federale Officer
Jim Henry
Guard