Danny Trejo
Machete Cortez
Mel Gibson
Luther Voz
Demián Bichir
Mendez
Amber Heard
Blanca Vasquez / Miss San Antonio
Sofía Vergara
Desdemona
Charlie Sheen
Mr. President
Jessica Alba
Sartana Rivera
Lady Gaga
La Camaleon
Alexa PenaVega
KillJoy
Vanessa Hudgens
Cereza Desdemona
Tom Savini
Osiris Amanpour
Cuba Gooding Jr.
El Camaleon
Antonio Banderas
El Camaleon
Walton Goggins
El Camaleon
William Sadler
Sheriff Doakes
Marko Zaror
Zaror
Julio Oscar Mechoso
Chepo
Billy Blair
Billy
Samuel Davis
Clebourne
Felix Sabates
Doc Felix
Electra Avellan
Nurse Mona
Elise Avellan
Nurse Lisa
Marci Madison
Nurse Fine
Callie Hernandez
Space Babe
Alejandro Antonio
Boss of Mendez
Crystal Martinez
Wife of Mendez
Corey Burton
Trailer Voice Guy (voice)
Elon Musk
Elon Musk
Emmy Robbin
Pris
Jason Christopher
Lieutenant Brass
Sam Medina
Cartel Leader
J.J. Perry
Voz's Henchman (uncredited)
Alexander Rodnyansky
Radio Guest (uncredited)
Vincent Fuentes
Cabrito Cook
Elle LaMont
Dollface
Jorge A. Jimenez
Dying Cartel Guy
Cheech Marin
Padre